Genetically engineered mice for cancer research design, analysis, pathways, validation and pre-clinical testing /
<p>Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors. This book provides an overview of the design considerations...
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| Format: | eBook |
| Language: | English |
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New York
Springer
2012.
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| Online Access: | Click here to view the full text content |
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Table of Contents:
- <p>Foreword
- Preface
- Overview of Designing Genetically-Engineered Mouse Models
- The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer
- Using Recombineering Technology To Create Genetically Engineered Mouse Models
- Insertional Mutagenesis for Generating Mouse Models of Cancer
- The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer
- Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat
- The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology
- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer
- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry
- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing
- Imaging mouse models of human cancer
- Identifying Mammary Epithelial Stem and Progenitor Cells
- Differentiation Programs in Development and Cancer
- Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse
- Mouse Models for Colorectal Cancer
- Src family tyrosine kinases: Implications for mammary tumor progression
- Maspin and Suppression of Tumor Metastasis
- Epigenetic Mouse Models
- Modeling Transforming Growth Factor-ß Signaling in Cancer
- Modeling Stromal-Epithelial Interactions.- Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.- Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models
- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models
- Animal Models for Breast Cancer Prevention Resarch
- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies
- Mouse Models in Preclinical Drug Development- Applications to CNS Models
- Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine
- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development
- Index. </p>.