Formation and cooperative behaviour of protein complexes on the cell membrane /
<p>With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of...
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| Materialtyp: | E-bok |
| Språk: | English |
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Berlin, Heidelberg
Springer Berlin Heidelberg
2012.
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| Serie: | Springer Theses
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| Länkar: | Click here to view the full text content |
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| Sammanfattning: | <p>With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process.</p> |
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| Fysisk beskrivning: | 1 online resource(XII, 80 pages) 46 illustration., 20 illustration. in colour. digital. |
| ISBN: | 9783642239885 |