Coarse-grained modelling of DNA and DNA self-assembly /
This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of s...
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| Format: | eBook |
| Language: | English |
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Berlin, Heidelberg
Springer Berlin Heidelberg
2012.
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| Series: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| Subjects: | |
| Online Access: | Click here to view the full text content |
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| Summary: | This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology. |
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| Physical Description: | 1 online resource (XI, 176 pages) 44 illustration, 25 illustration in colour, digital. |
| ISBN: | 9783642305177 |
| ISSN: | 2190-5053 |