Influenza virus sialidase - A drug discovery target /
<p>Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. <...
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| अन्य लेखक: | |
| स्वरूप: | ई-पुस्तक |
| भाषा: | English |
| प्रकाशित: |
Basel :
Springer Base,
2012.
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| श्रृंखला: | Milestones in Drug Therapy
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| विषय: | |
| ऑनलाइन पहुंच: | Click here to view the full text content |
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| सारांश: | <p>Influenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. </p><p>This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the<b> </b>haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.</p> |
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| भौतिक वर्णन: | 1 Online resource (IX, 178 pages) 58 illustration, 21 illustration in color, digital. |
| आईएसबीएन: | 9783764389277 |