Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression /
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation,...
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| المؤلف الرئيسي: | |
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| مؤلف مشترك: | |
| مؤلفون آخرون: | , |
| التنسيق: | كتاب الكتروني |
| اللغة: | English |
| منشور في: |
Basel
Springer Basel
2013.
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| سلاسل: | SpringerBriefs in Biochemistry and Molecular Biology
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| الموضوعات: | |
| الوصول للمادة أونلاين: | Click here to view the full text content |
| الوسوم: |
إضافة وسم
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| الملخص: | There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution. |
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| وصف مادي: | 1 online resource (VIII, 56 pages) 2 illustration in colour. |
| ردمك: | 9783034806794 |
| تدمد: | 2211-9353 |