Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression /

There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation,...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autor: Barrett, Lucy W. (Autor)
Korporativní autor: SpringerLink (Online service)
Další autoři: Fletcher, Sue, Wilton, Steve D.
Médium: E-kniha
Jazyk:English
Vydáno: Basel Springer Basel 2013.
Edice:SpringerBriefs in Biochemistry and Molecular Biology
Témata:
On-line přístup:Click here to view the full text content
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
Popis
Shrnutí:There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Fyzický popis:1 online resource (VIII, 56 pages) 2 illustration in colour.
ISBN:9783034806794
ISSN:2211-9353