Untranslated gene regions and other non-coding elements : regulation of eukaryotic gene expression /
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation,...
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| Andre forfattere: | , |
| Format: | eBog |
| Sprog: | English |
| Udgivet: |
Basel
Springer Basel
2013.
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| Serier: | SpringerBriefs in Biochemistry and Molecular Biology
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| Online adgang: | Click here to view the full text content |
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| Summary: | There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as "junk DNA", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution. |
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| Fysisk beskrivelse: | 1 online resource (VIII, 56 pages) 2 illustration in colour. |
| ISBN: | 9783034806794 |
| ISSN: | 2211-9353 |