Structural and functional characterization of the immunoproteasome /
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscop...
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| Формат: | eКнига |
| Язык: | English |
| Опубликовано: |
Cham
Springer International Publishing
2013.
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| Серии: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| Предметы: | |
| Online-ссылка: | Click here to view the full text content |
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| Итог: | In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis. |
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| Объем: | 1 online resource (XIX, 82 pages) 33 illustration, 29 illustration in colour. |
| ISBN: | 9783319015569 |
| ISSN: | 2190-5053 |