New gold-catalyzed reactions and applications for the synthesis of alkaloids /
Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as t...
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| Format: | E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer International Publishing
2013.
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| Schriftenreihe: | Springer Theses, Recognizing Outstanding Ph.D. Research
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| Online Zugang: | Click here to view the full text content |
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| Zusammenfassung: | Ana Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals. |
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| Beschreibung: | 1 online resource (XIII, 195 pages) 280 illustration, 41 illustration in colour. |
| ISBN: | 9783319007021 |
| ISSN: | 2190-5053 |