The Networking of Chaperones by Co-chaperones : Control of Cellular Protein Homeostasis /

Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecul...

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Corporate Author: SpringerLink (Online service)
Other Authors: Blatch, Gregory Lloyd (Editor), Edkins, Adrienne Lesley (Editor)
Format: eBook
Language:English
Published: Cham : Springer International Publishing : Imprint: Springer, 2015.
Series:Subcellular Biochemistry, 78
Subjects:
Online Access:Click here to view the full text content
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245 1 4 |a The Networking of Chaperones by Co-chaperones :  |b Control of Cellular Protein Homeostasis /  |c edited by Gregory Lloyd Blatch, Adrienne Lesley Edkins. 
264 1 |a Cham :  |b Springer International Publishing :  |b Imprint: Springer,  |c 2015. 
300 |a 1 online resource (xv, 276 pages)  |b 35 illustrations, 31 illustrations in color 
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490 1 |a Subcellular Biochemistry,  |x 0306-0225 ;  |v 78 
505 0 |a Preface -- List of Contributors- About the Editors- GrpE, Hsp110/Grp170, HspBP1/Sil1 and BAG domain proteins: Nucleotide exchange factors for Hsp70 molecular chaperones -- Functions of the Hsp90-Binding FKBP Immunophilins -- Hsp70/Hsp90 organising protein (Hop): beyond interactions with chaperones and prion proteins -- Specification of Hsp70 function by Type I and Type II Hsp40 -- Cdc37 as a Co-chaperone to Hsp90 -- p23 and Aha1- UCS proteins: chaperones for myosin and co-chaperones for Hsp90 -- Chaperonin - Co-chaperonin Interactions -- Co-chaperones of the mammalian endoplasmic reticulum -- The evolution and function of co-chaperones in mitochondria -- CHIP: a co-chaperone for degradation by the proteasome -- The role of HSP70 and its co-chaperones in protein misfolding, aggregation and disease -- Index. 
520 |a Co-chaperones are important mediators of the outcome of chaperone assisted protein homeostasis, which is a dynamic balance between the integrated processes of protein folding, degradation and translocation. The Networking of Chaperones by Co-chaperones describes how the function of the major molecular chaperones is regulated by a cohort of diverse non-client proteins, known as co-chaperones. The second edition includes the current status of the field and descriptions of a number of novel co-chaperones that have been recently identified. This new edition has a strong focus on the role of co-chaperones in human disease and as putative drug targets. The book will be a resource for both newcomers and established researchers in the field of cell stress and chaperones, as well as those interested in cross-cutting disciplines such as cellular networks and systems biology. 
650 0 |a Medicine. 
650 0 |a Life sciences. 
650 0 |a Biochemistry. 
700 1 |a Blatch, Gregory Lloyd.  |e editor. 
700 1 |a Edkins, Adrienne Lesley.  |e editor. 
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